Subcutaneous administration of nicotine changes dorsal raphe serotonergic neurons discharge rate during REM sleep.
نویسندگان
چکیده
In the present study nicotine (0.1 mg/kg, s.c.) increased discharge rate of putative dorsal raphe (DRN) serotonergic neurons of behaving rats during REM sleep (362.61%), without any significant change during waking and non-REM sleep. Since serotonergic DRN neurons gate PGO onset, these results suggest that nicotine-induced suppression of PGO spikes during REM sleep previously reported is achieved through stimulation of dorsal raphe serotonergic cells.
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ورودعنوان ژورنال:
- Brain research
دوره 888 2 شماره
صفحات -
تاریخ انتشار 2001